Brenton Hoffman, PhD
James L. and Elizabeth M. Vincent Associate Professor of Biomedical Engineering
Associate Professor in the Department of Biomedical Engineering, Pratt School of Engineering
A major goal of my research is to elucidate the molecular mechanisms cells utilize to detect, interpret, and respond to mechanical cues, such as internally-generated or externally-applied force as well as changes in the physical properties of the extracellular environment. This process is called mechanotransduction and is increasingly recognized as critically important in fundamental cellular processes like cell migration, physiological processes like wound healing, and pathophysiological processes like fibrosis. Specifically, my laboratory creates new tools and approaches to facilitate the discovery, understanding, and manipulation of the biophysical and biochemical processes that mediate mechanotransduction.
